Compounded Medication

Trimix Solution From a 503A Compounding Pharmacy

MediVera Compounding Pharmacy™ compounds the Trimix formulations listed on this page for your patients, plus customized strengths as you prescribe them.
Trimix solution vial with two capped dosing syringes on a pale cool-gray studio background

About Trimix Solution

Trimix is a compounded injectable formulation containing a combination of three medications, alprostadil, papaverine, and phentolamine, prepared based on prescriptions from licensed providers to meet individual patient needs.

At MediVera Compounding Pharmacy™, we prepare Trimix formulations in accordance with USP 795, 797, and 800 in our Troy, Michigan facility.

MediVera holds dual PCAB accreditation in sterile and non-sterile compounding, held by fewer than 1% of compounding pharmacies in the United States, and every batch goes through independent third-party potency, sterility, and endotoxin testing before release. Your practice can work with one Trimix compounding pharmacy for patients across 49 states plus Washington, D.C., where MediVera is licensed.

Medication Information + Usage

Each formulation code lists PGE1 in mcg/ml, then phentolamine and papaverine in mg/ml, and customized strengths are also available on a licensed provider’s prescription.

  • “5-0.5-15” Papaverine 15mg/ml, Phentolamine 0.5mg/ml, PGE1 5mcg/ml
  • “10-1-30” Papaverine 30mg/ml, Phentolamine 1mg/ml, PGE1 10mcg/ml
  • “20-1-30” Papaverine 30mg/ml, Phentolamine 1mg/ml, PGE1 20mcg/ml
  • “20-2-30” Papaverine 30mg/ml, Phentolamine 2mg/ml, PGE1 20mcg/ml
  • “50-2-30” Papaverine 30mg/ml, Phentolamine 2mg/ml, PGE1 50mcg/ml

All preparations should be kept in the refrigerator. If you travel, use a travel kit designed to keep medication cool. Freezing the medication before travel can also extend periods without refrigeration.

*Compounded medications referenced are not reviewed by the FDA for safety or effectiveness and are prepared by prescription for individual patients. Providers are solely responsible for determining their appropriateness.

Trimix Solution FAQ

Providers can prescribe through any of these routes. • FAX: Contact us at [email protected] to request a fax form and a suggested dosing schedule. • EMR: Submit prescriptions directly through your EMR system. • Phone: Call us at 877-531-1147 to speak with our team and place your prescription.

• Provider Portal: Use our Provider Portal for online prescribing.

MediVera compounds Trimix Solution only on an individualized prescription from a licensed healthcare provider, and that provider decides whether it is appropriate for the patient. You can send the prescription through any of the prescribing routes in the answer above.

Each Trimix Solution prescription is compounded under USP 795, 797, and 800, and each batch receives independent third-party testing for potency, sterility, and endotoxin before it leaves our facility. Our pharmacy is dual PCAB-accredited for sterile and non-sterile compounding, and full batch documentation is available on request.

MediVera is licensed in 49 states plus Washington, D.C., so a filled Trimix Solution prescription can reach your patient in any of them. If you are unsure whether a patient’s state is covered, call our team at 877-531-1147 before you send the prescription.

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